Abstract

DESIGN SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY ON A NEW SERIES OF 1,2,3,4 TETRA HYDROCARBAZOLES

N. Vijaya Lakshmi*, B. Sarwani, V. Divya Teja, Sk. Kaashefah Jinaan and J. Chiranjeevi

ABSTRACT

Carbazole is an aromatic heterocyclic organic compound. It has a tricyclic structure, consisting of two six-membered benzene rings fused on either side of a five-membered nitrogen-containing ring. The compound's structure is based on the indole structure. The tetrahydo carbazole ring system has been structural subunit of many naturally occurring alkaloids, biologically active molecules and medicinal important synthetic analogues. 1,2,3,4-tetrahydocarbazoles are well known for their pharmacological activities and several newer physiologically active compounds. Present work deals with the synthesis of 9-(benzyl)1,2,3,4 - tetra hydrocarbazole and their antibacterial activity. The synthesized compounds are characterized by using melting point, TLC, IR, NMR- Spectroscopy, Mass Spectroscopy. The synthesized compounds are evaluated for their antibacterial activity by cup-plate method using gram negative and gram positive cultures. Some of the derivatives like TCZ 3a, TCZ4a, TCZ 3b,TCZ4b are having significant antibacterial and anti fungal activity by showing zone of inhibition.

Keywords: Carbazoles, tetrahydrocarbazoles, melting point, IR, TLC, NMR-Spectroscopy, Mass spectroscopy, Recrystallization.