Abstract

DIAGNOSIS OF HELICOBACTER PYLORI INFECTION IN DYSPEPTIC PATIENTS IN SALAHALDIN GOVERNORATE: SEROLOGICAL VERSUS HISTOPATLIOLOGICAL STUDY

Dr. Taha. I. Mohamed*, Dr. Saleh Abdulrazzaq Dalaf, Dr. Muheeb A. Salih, Prof. Muheeb A. Salih and Prof. Muheeb Ahmed Sammari

ABSTRACT

Background: Helicobacter pylori (H. Pylori) is Gram negative motile flagellated bacteria; infection is likely acquired in childhood. H.pylori is recognized as a cause of gastritis and peptic ulcers. H.pylori infection is diagnosed by non-invasive test (serology) and invasive test (histopathology) used for dyspeptic patients. The gold stander for diagnosis of H.pylori; is the histological examination of gastric biopsy stained by Giemsa stain. Aim: To evaluate the reliability of non-invasive test (serology); particularly rapid whole blood test for H. Pylori infection in comparison with the invasive test (histopathology) in the diagnosis of H. Pylori infection ,and to recognize the affect of many factors, such as age, gender and residency on the prevalence of H. pylori infection. Methods: Study of 58 patients (22 male; 36 female); age range 18-74 years mean age 46 years. who underwent OGD) with biopsy two from antrum and two from body of stomach stained by Giemsa stain, taken from dyspeptic patients, to compared with the non-invasive test (serology). Results: H. pylori was diagnosed serologically in 35(60.34%) patients of the study sample, while only 28(48.27%) patients was diagnosed by histopathologieal study. H.pylori prevalent in age group over 45years(66.66%) versus (57.5%) in age group less than 45years old. H.pylori more prevalent in female than male(61.1%), (59.09%) respectively. H.pylori more prevalent in rural than urban area(56.75%) versus(61.6%) respectively by serology. The most common endoscopic findings in patients with dyspepsia is normal endoscopic finding 33%(19/58), while the less common endoscopic finding is gastric tumor 1.5%( 1/58). The prevalence of H.pylori is more in smoker than nonsmoker(75%)versus (56.5%) respectively. The overall diagnosis of H.pylori infection by serology was 60.34%(35/58) while histological diagnosis is 48.2%(28/58). Conclusions: Endoscopy is the most important procedure and should be undertaken in any patient with alarming signs of dyspepsia. Rapid whole blood test(serology) consider as an indicator of H.pyori infection whether itis acute or chronic and suitable for screening test of H.pylori in dyspeptic patients. Serological evidence of H.pylori infection was consistently greater than the prevalence of infection documented by histopathologieal methods.

Keywords: Helicobacter pylori (H. Pylori), non-invasive test (serology) and invasive test (histopathology).