Abstract

A COMPREHENSIVE REVIEW ON SOLID DISPERSIONS

VNS Jahnavi, S. Bhagya Laxmi, B. Sireesha, K. Geetha Sri, K. Preethi Sobha Sri, P. M. M. Naga Lakshmi Varma* and K. Padmalatha

ABSTRACT

Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate of poorly water-soluble drugs to enhance their bioavailability. Poor water solubility is one of the major drawback for the various types of drugs and various approaches have been introduced for the enhancement of solubility of such drugs. The solubility behaviour of drugs is one of the most challenging aspects for formulation development. Currently 10-12% of new drug candidates have both high solubility and high permeability. About 60-65% of the potent drug products suffers from poor water solubility. Solid dispersions are one of the most promising strategies to improve the oral bioavailability of poorly aqueous soluble drugs by reducing drug particle size to the absolute minimum, increasing surface area and hence improving drug wettability, bioavailability may be significantly improved. Solid dispersions are generally prepared with a drug which is having poor aqueous solubility and with a water soluble hydrophilic carrier. Solid dispersions, defined as the dispersion of one or more active pharmaceutical ingredient in a carrier at solid state and are obtained by two different methods i.e. melting and solvent evaporation usually presenting in an amorphous form.

Keywords: Solid dispersion, carrier, dissolution enhancement.