Abstract

SYNTHESIS AND ANTI-MICROBIAL SCREENING OF SOME NOVEL N-(5-BENZYL- 1, 3, 4-OXADIAZOL-2-YL)-2-CHLOROACETAMIDE AMINO DERIVATIVES

Gomathy Subramanian*, Mithra, Gowramma Byran, Farhath Sherin, Ashish D. Wadhwani

ABSTRACT

Objective: The objective of this study is to synthesize some novel N-(5-Benzyl-1, 3, 4-oxadiazol-2-yl)-2-substituted chloroacetamide derivatives and to study their anti-microbial activity. Materials and Methods: Condensation of hydrazine carboxamide with phenyl acetic acid gave 2-benzyl-1,3,4-oxadiazole amine (I) which on treatment with chloroacetyl chloride at 80 °C yielded N-(5-benzyl-1,3,4-oxadiazol-2-yl)-2-chloroacetamide (II). Further, compound II reacted with various substituted amines in presence of glacial acetic acid to furnish N-(5-benzyl-1, 3, 4-oxadiazole-2-yl)-2-acetamide derivatives. The structures of the synthesized compounds have been established based on their analytical and spectral data. Results: The synthesized compounds were evaluated for their anti-microbial screening using in vitro free radical scavenging assay for their antibacterial activities. Compounds III a exhibited significant antibacterial activity. Conclusion: The obtained results clearly revealed that most of these derivatives showed promising broad spectrum antibacterial activity when compared to that of the standard drugs. We appreciate further detailed studies with these drugs as potential antimicrobial agents.

Keywords: 1, 3, 4-oxadiazole, anti-microbial activity, Escherichia coli, Streptococcus aureus.