Abstract

CONTROLL RELEASE DRUG DELIVERY SYSTEM

Shete Nikhil Arun*, Mohan R. S., Gore S. J., Tagad R. R. and Darade S. B.

ABSTRACT

Oral route has been the most popular and preferred and most patient-convenient means of drug administration because is release the drug for long period of time at predetermined manner. The immediate release conventional dosage form lack in the efficiency of controlling the proper plasma drug concentration and in case of IR tablet frequency of administration is more so the need to develop the controlled release dosage form. The development of controlled release drug delivery system is need because to overcome the problem of repetitive dosing and unpredictable absorption, less bio-availability and variations in the drug plasma concentration. The main objective of these dosage forms is to overcome the problem of uncertain fluctuations in the IN-VIVO environment due to uncontrolled or uneven release of drug and to increase the bioavailability and reduce the frequency of administration of drug. There are different aspects or approaches for design of controlled release drug delivery systems such as, matrix, reservoir, osmotic pressure, ion exchange resins, altered density etc. This article contains brief review on currently existing controlled release drug delivery system (CRDDS) and various formulation approaches for the controlled release system.

Keywords: controlled, liposomes, absorption, predetermined.