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EFFECT OF AMLODIPINE AND LYCOPENE IN AMELIORATION OF RENAL TOXICITY INDUCED BY CISPLATIN IN ALBINO RATS
Hanan A. Rizk, Ashraf Elkomy, Samar S. Ibrahim and Mohamed M. Elmahalawy*
ABSTRACT
The present research investigated whether Amlodipine and Lycopene could ameliorate the Cisplatin induced renal toxicity in rats. 80 male albino rats were randomly assigned into 8 equal groups (10 rats each). Group 1: Rats which served as Control group were injected (IP) saline once daily for 20 days. Group 2: Rats in this group were served as Saline group and were administrated orally 1 mL saline once daily for 20 days. Group 3: Rats in this group were served as Corn Oil group and were administrated orally 1 mL Corn Oil once daily for 20 days. Group 4: Rats in this group were served as Amlodipine group and were administrated orally (5 mg/kg/day) Amlodipine once daily for 20 days. Group 5: Rats in this group were served as Lycopene group and were administrated orally (10 mg/kg/day) Lycopene once daily for 20 Keywords: Cisplatin, Amlodipine, Lycopene, Renal toxicity. [Download Article] [Download Certifiate] |