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ANTIDIABETIC, ANTIHYPERLIPIDEMIC, ANTIOXIDATIVE EFFECTS OF RIDA HERBAL BITTERS IN STREPTOZOTOCIN-INDUCED DIABETIC MALE WISTAR RATS
Ajao Folasade Omobolanle*, Oyadeyi Ayodele Stephen and Abiola Samad
ABSTRACT
This study aimed at investigating antidiabetic, antihyperlipidaemic and antioxidant profile of RIDA herbal bitters in diabetic male Wistar rats. Thirty-two (32) male Wistar rats were randomly divided into control and experimental groups of n = 8. The experimental rats were administered intraperitoneal single dose of freshly prepared streptozotocin (50 mg/kg b.w) dissolved in 0.1M citrate buffer (pH 4.5) after 12 h fasting period. On the establishment of diabetes, food consumption was monitored daily. Fasting blood glucose level and body growth rate were determined on 1st, 3rd and 7th day. Biomarkers of oxidative stress, lipid peroxidation markers kidney and liver function tests were determined post treatment. Pancreas were excised Keywords: Diabetes mellitus; RIDA bitters; Hyperglycaemia; Oxidative stress; Lipid profile. [Download Article] [Download Certifiate] |