Abstract

ESTIMATION OF METOCLOPRAMIDE. HCL IN PHARMACEUTICAL PREPARATIONS AND ENVIRONMENTAL WATER SAMPLES.

Nief Rahman Ahmed*, Nadia Cheni Saadallah and Amenah Ibrahim Ahmed

ABSTRACT

A simple, rapid, accurate and sensitive spectrophotometric method for determination of Metoclopramide hydrochloride has been developed. The proposed method is based on the reaction between chloride ion and mercuric thiocyanate, formation of a colored complex by the reaction between released thiocyanate and ferric ions to form red soluble product with maximum absorption at 462 nm. Beerˈs law is obeyed over the concentration range of 2-30μg/ml, with molar absorptivity of 1.0x104 l/mol.cm. The present method is considered to be simple because it does not need either heating or hydrolysis or solvent extraction steps. The ingredients often formulated with Metoclopramide hydrochloride have been shown not to interfere, and the proposed method is suitable for the routine determination of Metoclopramide hydrochloride. The method has been successfully applied for the determination of Metoclopramide hydrochloride in pure form, pharmaceutical preparations(Tablets) and environmental water sample.

Keywords: Metoclopramide Hydrochloride, Mercuric thiocyanate.