Abstract

LIPID-BASED NANOPARTICULATE DRUG DELIVERY: SYNTHESIS PROSPECTIVE AND THEIR BIOMEDICAL APPLICATIONS.

Tagad Rupesh*, Gore Shubham, Mohan Rahul, Kotame Radhika, Somwanshi Rahul

ABSTRACT

Solid lipid nanoparticles (SLN) are rapidly developing field of nanotechnology with several potential applications in drug delivery and research. Due to their unique size dependent properties, lipid nanoparticles offer possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting. Even the enhancement of solubility and bioavailability of poorly soluble drugs should be carried out using different biodegradable and bioacceptable polymers which can also overcome the toxic effects of traditional drug carrier system. The different types of nanocarriers which were based on solid lipid like solid lipid nanoparticles, nanostructured lipid carriers, lipid drug conjugates are discussed with their structural differences. Different production methods which are suitable for large scale production and applications of solid lipid nanoparticles are described. This review presents broad applications of solid lipid nanoparticles discussing their aims, production procedures, advantages, limitations.

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