Abstract

FORMULATION AND EVALUATION OF FUROSEMIDE FAST DISSOLVING TABLETS

A Salomy Monica Diyya* and Dr. Noel Vinay Thomas

ABSTRACT

Solid dosage forms are popular because of ease of administration, accurate dosage, self-medication, pain avoidance and most importantly the patient compliance. Out of many oral solid dosage forms, fast dissolving tablets have gained much importance. These are not only indicated for people who have swallowing difficulties but also are ideal for active people. This dosage form dissolves and disintegrates in the oral cavity within minutes without need of water or chewing. The benefits in terms of patient compliance, rapid onset of action, increased bioavailability, rapid absorption through pre-gastric absorption of drugs from the mouth and stability. Thus the bioavailability of drugs is significantly more than those observed from conventional tablets dosage form. In the present study, Furosemide, potent loop diuretic is our drug of choice. It’s oral bioavailability 43-69% due to first pass metabolism. Hence its bioavailability can be increased by formulating it into fast dissolving tablets there by avoiding first pass metabolism. Furosemide fast dissolving tablets are formulated by direct compression method using super disintegrants. In this study, crospovidone, croscarmellose and sodium starch glycolate are used as super disintegrants in varying concentrations of 5%, 5.6% and 6.4%. Evaluation tests for precompression blend which include drug authentication studies, angle of repose, bulk density, tapped density, compressibility index, hausner’s ratio are carried out. Evaluation tests for post compression blend which include thickness test, hardness test, friability test, weight variation test, disintegration test, in vitro dissolution test are carried out. Out of all formulations, the formulations with crospovidone as super disintegrant has shown faster disintegration. The formulation, F3 having 6.5% crospovidone as superdisintegrant has shown 99% drug release at the end of 10-minute time interval.

Keywords: Furosemide, fast dissolving tablets, superdisintegrants, disintegration test, in-vitro dissolution test.