Abstract

SPHERICAL CRYSTALLIZATION –A NOVEL DRUG DELIVERY SYSTEM

Mohan R. S.*, Karad P. B., Gore S. J., Tagad R. R.

ABSTRACT

Spherical crystallization is the novel agglomerated technique that can directly transform the fine crystals produced in the crystallization process into a spherical shape. It is the particle engineering technique by which crystallization and agglomeration can be carried out simultaneously in one step to transform crystals directly into compacted spherical form. This technique of particle design of drugs has emerged as one the areas of active research currently of interest in pharmaceutical manufacturing and recently came into the forefront of interest or gained interest due to the fact that crystal habit can be modified during crystallization process which would result in better micrometric properties like particle size those can enhance the flow ability of the powder drug and prepared spherical crystals can be compress directly without performing granulation, drying and so many steps those are require in wet granulation and in dry granulation process of tablet manufacturing. Spherical crystallization of drugs is the process of obtaining larger particles by agglomeration during crystallization. The most common techniques used to obtain such particles are spherical agglomeration and quasi-emulsion solvent diffusion. Ammonia diffusion systems and crystalloid- co-agglomeration are extensions of these techniques.

Keywords: Spherical crystallization, Drug, Techniques, agglomeration, solvent diffusion, improved particle properties.