Abstract

MUCOADHESIVE MICROSPHERES: A REVIEW ON EMERGING TREND IN NASAL DRUG DELIVERY

Anjali Mishra*, Hariom Sharma and Monika Seti

ABSTRACT

Over the past few decades, there has been a considerable shift form conventional drug delivery system to novel drug delivery system in pharmaceutical field. The main reason behind this approach is to increase the safety, efficacy and reduce the toxicity of drugs. Microspheres are one such novel drug delivery system that increases plasma drug concentration of drug, prolongs its action, which in turn reduces dosing frequency of dosage forms. Patient compliance also increases when sustain release action is attained. The advantage of mucoadhesive microspheres is that, it remains in close contact with the mucous membrane due to bio-adhesion thus releasing the drug at targeted site and increasing bioavailability. The aim of this article is to understand mucoadhesion and to emphasize its application in nasal drug delivery system.

Keywords: Microspheres, Mucoadhesion, Patient compliance, Bioavailabilty, Nasal Drug Delivery.