Abstract

TARGETABLE MICELLPLEX HYDROGEL AS A SMART THERAPEUTIC STATEGY FOR CANCER AND SIRNA DELIVERY

Shubham Gore*, Niteen Ghule, Rahul Mohan, Radhika Kotame and Rupesh Tagad

ABSTRACT

Micelleplexes are a class of nucleic acid transporters that have earned acceptance because of their size, strength, and capacity to synergistically carry small molecules. The targetable micelleplex hydrogel is another promising system for the delivery of siRNA and a drug that functions as a targetable gene carrier. Thus the hydrogel is responsible for controlling the release of siRNA and minimizing the disadvantages associated with systemically administered siRNA carriers by decreasing the fluctuations in their level in the serum. This review presents recently gained knowledge and develops the field of delivering therapeutic oligoribonucleotides and using micelleplexes as authentic carriers. The polymeric micelles of the micelleplexes form complexes with siRNAs and are transformed into gels when they are administered subcutaneously. The release of the contents of the gel is controlled. The discharged micelleplexes specifically collect in the tumor and demonstrate an anti-tumor effect because of long-term gene silencing and show prolonged release when once dose is injected in vivo.

Keywords: Hydrogel; siRNA; Controlled release; Gene delivery.