Abstract

A REVIEW ARTICLE ON NANOPARTICLES

Jyoti Saxena*, Pranshu Tangri, Shaffi Tangri and N. G. Raghvendra Rao

ABSTRACT

Nanoparticles (NPs) are those particles that exist on a nanometre (nm) scale (i.e below 100 nm in at least one dimension). Design, characterisation, production and application of structure, devices and system by controlling shape and size at nm scale is refer to nanotechnology. By this we can achieve better therapeutic effect, better bioavailability and better patient compliance. Nanoparticles can be synthesised chemically or biologically. They can be classified into different classes based on their properties, shapes or sizes. It includes metal nanoparticles, ceramic nanoparticles and polymeric nanoparticles and it also possess unique physical and chemical properties due to their high surface area and nano size scale. Different techniques are used for the preparation of nanoparticles such as solvent evaporation technique, nanoprecipitation (solvent displacement), salting out, emulsion polymerisation, interfacial complexation, dispersion polymerisation etc. Nanoparticles are prepared by above methods then prepared nanoparticles are evaluated by some parameters includes drug content or drug entrapment, particle size and shape, yield of nanoparticles, DSC, in-vitro drug release and stability of nanoparticles.

Keywords: Nanoparticles, characterisation of nanoparticles, methods of preparation of nanoparticles and evaluation parameters of nanoparticles.