Abstract

A COMPREHENSIVE REVIEW ON BUCCAL DRUG DELIVERY SYSTEM

Fariya Mozammel, Irin Dewan, S. M. Ashraful Islam*

ABSTRACT

Drug administration through the mucosal membranes (buccal mucosa) is known as buccal drug delivery. It has been introduced in 1947 when dental adhesive powder and gum tragacanth were mixed to apply penicillin to the oral mucosa.[1] Oral route is perhaps the most preferred by patients and clinicians alike among the various routes of drug delivery.[2] Fifty percent (50%) commercially available drugs are administered through oral drug delivery system and this system has more advantages due to ease of administration and patient acceptance.[3] But certain drugs have lack of efficacy due to decreased GI intolerance, bioavailability, unpredictable absorption, pre-systemic elimination etc. In comparison to the conventional oral medications retentive buccal mucoadhesive formulations may prove to be a viable alternative as they can be readily attached to the oral mucosa (Figure 1-2), retained for a longer period of time and can be removed at any time.[4]

Keywords: .