Abstract

AWARENESS OF INTERACTIONS OF NSAIDS WITH SOME DISEASES AMONG PHARMACISTS IN KHARTOUM STATE

*Fahad Gasim Alsiddig Alabass, Ahmed Mustafa Khidir and Ali Awad Allah Ali Moh. Saeed

ABSTRACT

Introduction: Drug- Disease interactions may cause deterioration in the patient’s clinical status, resulting in additional treatment, hospitalization, and/ or an extended hospital stay. NSAIDs inhibit the enzymatic production of prostaglandins. In Sudan and prescribing are more than other drugs or may be used routinely by more patient by them self without sufficient know –how the effect of (NSAIDs) if they have other diseases e.g., Asthma, gastrointestinal upset (peptic ulcer). Objectives: To assess the extent of awareness of drug-diseases interactions of NSAIDs among Pharmacists and Doctors in Khartoum state pharmacies and hospitals. Materials and methods this study was conducted in Khartoum state pharmacies and hospitals during the period of May to 15Th October 2011, it is cross-sectional study. Sample size 120 of pharmacists and 50 doctors working in Khartoum state hospitals will be selected randomly. Structured pre tested questionnaire will be developed to collect the data. Moreover, the information was collected from books, international journals. BNF and scientific websites. The analyzing of data using SPSS program. Results: 76% of doctor expected that there will be drug-drug or drug-disease interaction between asthmatic patients and NSAIDs. 75.5% from the pharmacists stated that NSAIDs may interact with asthmatic patients by worsening the asthma. 91.67% of doctors expected that there will be drug-disease interaction between ulcerative patients and NSAIDs. 88% stated that the interaction by increasing gastric acid secretion and worsening of the ulcer in these patients. 55.5% from the doctors did not ask the patients about the period of using NSAIDs when they come to take NSAIDs. Conclusion: More than half of the practicing pharmacists and medical doctors are aware about the interaction between NSAIDs and asthma, hypertension and patients having ulcer. Unfortunately in spit of that, they dispense and prescribe NSAIDs to these patients respectively. Half of the doctors did not ask the patients about the period of using NSAIDs when they come for treatment. Half of the pharmacists are reluctant to ask the patients about the medical history when they are taking NSAIDs.

Keywords: Interactions, NSAIDS with Diseases.