Abstract

NIOSOMAL IN-SITU GEL DRUG DELIVERY: A REVIEW

Sachin C. P.*, Gowtham M. and Vimal V. V.

ABSTRACT

Eye is the most vital organ of the body. Most ocular diseases are treated by topical drug application in the form of solutions, suspensions and ointment. The major drawback associated with conventional ophthalmic formulations is quick precorneal drug loss resulting in poor bioavailability and therapeutic response, because of high tear fluid turnover and dynamics. In- situ gelling ophthalmic drug delivery system is developed to overcome this bioavailability problems. In-situ forming gels are solutions, instilled as drops into the eye and undergo a sol- to-gel transition in the cul-de-sac. Drug delivery through niosome is one of the approaches to achieve localized action and it result in enhancement of efficiency of same drug and at the same time reduces its systemic toxic effects. Thus, niosomes entrapped through in-situ gel system has been developed to increase precorneal residence time, to minimize interference with blinking, enhance ocular bioavailability and reduce frequency of the administration of drug. The aim of this article is to present a concise review of niosomal in-situ gelling system to overcome conventional ophthalmic dosage forms problems.

Keywords: Niosomes, In-situ gelling systems, Temperature sensitive, pH sensitive, Ion sensitive.