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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

BIO-ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR APLIDINE IN RAT PLASMA AND THEIR PHARMACOKINETIC STUDIES BY LCMS

Asha Eluru* and Dr. K. Surendra Babu

ABSTRACT

A simple, sensitive and rapid chromatographic method was developed and validated for quantification of Aplidine in rat plasma using Dexamethasone as internal standard. Chiral cell ODH (2.1x150mm, 5μ) column provided chromatographic separation of analyte followed by detection with mass spectrometry. The method involved simple isocratic chromatographic condition and mass spectrometric detection in the positive ionization mode using a QTRAP- 5500 system. The total run time was 10 min. The proposed method has been validated with the linear range of 5-75 ng/ml of Aplidine. The intraday precision and interday precision %RSD values were within the limit. The overall recovery of Aplidine was 98.1% - 99.2% respectively.

Keywords: Aplidine, Bio-analytical method, LCMS.

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