Abstract

FORMULATION AND EVALUATION OF MUPIROCIN GEL AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS IN BURN WOUND INFECTION

Sudhir, Navneet Kaur and Sweety Birla*

ABSTRACT

The aim of present work is to develop and evaluate mupirocin gel against methicillin resistant staphylococcus in burn wound infection. Gel were prepared with the help carbopol gel base which was produced by hot method. Mupirocin were incorporated into carbopol gel base by magnetic sterring. Mupirocin gel shows pH 7.2. The viscosity of mupirocin gel was found to be 73,200 cp. The spreadability of mupirocin was found to be 12.66 g.cm2 /sec. The % yield of mupirocin gel was found to be 95.68%. In vitro release study show 97.4% release of drug, stability is good with effective antibacterial activity. It was observed that the first order model was found to be best suited with R2 values of 0.9826. First order model be used to describe the drug dissolution for, several types of modified release pharmaceutical dosage forms.

Keywords: Mupirocin, carbopol gel, antibacterial activity, staphylococcus aureus.