Abstract

FORMULATION AND EVALUATION OF EFFERVESCENT FLOATING TABLETS OF DOMPERIDONE

K. Satheesh*, Dr. Y. Krishna Reddy, Syed Suhaib Ahmed and Shaistha

ABSTRACT

The present study was undertaken to prolong the release of orally administered drug. The objective of the study was to formulate the sustained release floating tablet of Domperidone. The floating tablets of Domperidone were prepared by direct compression method. For this, polymers like HPMC K4M, Sodium CMC and Carbopol p934 were used in various concentrations. Sodium bicarbonate was used as a floating effervescent agent. The formulations were evaluated for various physical parameters, floating lag time, In-vitro drug release. From the results obtained, Formulation F9 gives desirable Sustained effect for 12 hours having 98.42% drug release at the end of the 12 hours. formulation F9 contain Carbopol p934 in concentration 2 mg.

Keywords: Domperidone, HPMC K4M, Sodium CMC and Carbopol p934, Floating Tablets.