Abstract

FORMULATION AND INVITRO EVALUATION OF DOXOPHYLLINE ORAL DISINTEGRATING TABLETS

Syed Suhaib Ahmed*, Dr. Y. Krishna Reddy, Shaistha and K. Satheesh

ABSTRACT

The aim of this research is to formulate and evaluate Doxophylline Oral disintegrating Tablets. Doxophylline Indicated for the treatment of chronic obstructive pulmonary disease (COPD), bronchial asthma and pulmonary disease with spastic bronchial component. Hence in this investigation an attempt was made to develop oral disintegrating tablets of Doxophylline with super disintegrating agents like Sodium starch glycolate (SSG), Crospovidone and Ac-Di-Sol. With superior dissolution properties with different concentrations. The tablets were prepared by direct compression method. The tablets were evaluated for the pre compression parameters such as bulk density, compressibility, angle of repose etc and post compression parameters like Hardness, weigh variation, friability, disintegration time, In vitro dissolution studies. The formulation F6 consisting of Crospovidone was found be best among all the formulations it has exhibited faster disintegrating time (15 sec) when compared to other formulations and it showed 99.57% drug release in 30min.

Keywords: Doxophylline Oral disintegrating Tablets, Sodium starch glycolate (SSG), Crospovidone and Ac-Di-Sol.