Abstract

RECENT ADVANCES IN NOVEL DRUG DELIVERY SYSTEM BY USING SUBLINGUAL FORMULATION

Rima Patel*, Prachi Patel and Anil Raval

ABSTRACT

Drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. Sublingual route is a rapid onset of action and better patient compliance than orally ingested tablets. Sublingual literally meaning is “under the tongue”, administrating substance via mouth in such a way that the substance is rapidly absorbed via blood vessels under tongue. The portion of drug absorbed through the sublingual blood vessels bypasses the hepatic first‐pass metabolic processes giving acceptable bioavailability. Peroral administration of drug has disadvantages such as Hepatic first pass metabolism and enzymatic degradation within the GI tract that limits oral administration of certain classes of drug like peptides and proteins. So, other absorptive mucosa is considered as potential sites for drug administration. Trans-mucosal routes of drug delivery (i.e. the mucosal linings of the nasal, rectal, vaginal, ocular, and oral cavity) offer several advantages over peroral administration for systemic delivery. Different techniques are used to formulate the sublingual dosage forms. New sublingual technologies for patient needs enhanced life‐cycle management to convenient dosing for geriatric, paediatric and psychiatric patients with dysphagia. This review highlights advantages, disadvantages and different sublingual formulation such as tablets and films, evaluation.

Keywords: Sublingual delivery, Oral cavity, Dysphagia, Improved bioavailability, Evaluation.