Abstract

A BRIEF REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEM- PATCHES

Amit A. Wagh*, Nikam R. J. and Shelar S. A.

ABSTRACT

Merriam Webster dates the word “transdermal” to 1944 highlighting that it is a relatively recent concept in medical and pharmaceutical practice, In brief TDDS (Transdermal drug delivery system) In order to deliver therapeutic agents through the human skin for systemic effects, the comprehensive morphological, biophysical and physicochemical properties of the skin are to be considered. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. It promotes healing to an injured area of the body. An advantage of a transdermal drug delivery route over other types of delivery system such as oral, topical, intravenous, intramuscular etc. The patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication, embedded in the adhesive also allows continuous input of drugs with short biological half-lives and eliminates pulsed entry into systemic circulation, which often causes undesirable side effects. This review article describes the overall introduction of transdermal patches including type of transdermal patches, method of preparation of transdermal patches and factor affecting etc.

Keywords: Transdermal, transdermal patches, Poly., TDDS.