METHOD DEVELOPMENT AND VALIDATION FOR MELOXICAM AND IBUPROFEN IN COMBINE PHARMACEUTICAL DOSAGE FORMS BY RP – HPLC
*Shaik Murtuza and S. Harshini M.Pharm
ABSTRACT
A new method was established for simultaneous estimation of a Meloxicam and Ibuprofen by RP-HPLC method.
The chromatographic conditions were successfully developed for the separation of Meloxicam and Ibuprofen by using:
- Inertsil -ODS C18(250 x 4.6 mm, 5μ),
- flow is 1.0 ml/min.
- mobile phase ratio was Water and Acetonitrile (80:20).
- detection wave length was 220 nm.
Keywords: ? Meloxicam and Ibuprofen, ? RP-HPLC, ? Acetonitrile.
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