Abstract

EVALUATION OF ANTI-ARTHRITIC ACTIVITY USING METHONOLIC EXTRACT OF CURCUMA ANGUSTIFOLIA ROXB RHIZOMES

Navneet Dehariya*, Dr. Rupesh Kumar Pandey, Anees Ghosi, Namrata Gupta, Amit Namdev

ABSTRACT

Background: -Tikhur (“Curcuma angustifolia roxb.”) is rhizomatous herb. This species is native to the Indian sub-continent and is more frequently recognized as wild or East Indian Arrowroot or narrow-leaved turmeric in English. The plant is most commonly found growing wild in India especially in the East and Western coastal plains and hills. It is used for the various pharmacological conditions like anti-ulcer, anti-tubercular, cough and bronchitis, cooling agents for the stomach and human body etc. Aim: -The present study was designed to investigate the anti-arthritis potential of the plant “Curcuma angustifolia roxb.” Materials: -The rhizomes part of the plant “Curcuma angustifolia roxb” was collected, washed and dried at room temperature. The dried plant material was grounded into coarse powder and extracted (maceration) with Methanol. Preliminary phytochemical studies were carried out. Methods: -All the in-vitro models i.e. Carrageenan induced arthritis and formaldehyde induced arthritis were carried out with standard reference drug Aspirin. Result: -Dose dependent and significant (0.05) activity in-vitro models were found. Conclusion: -The results reveal promising anti-arthritic potential of the plant. However further pharmacological investigation using isolated active ingredients can be carried out to confirm its efficacy and mechanism of action.

Keywords: Anti-arthritic activity,“Curcuma angustifolia roxb.”, carrageenan induced arthritis and formaldehyde induced arthritis.