Abstract

A SIMPLE SPECTROPHOTOMETRIC ESTIMATION OF EDARAVONE IN BULK SAMPLES

G. Srihari, U. Srinivasulu*, K. Prabhavathi and N. Rami Reddy

ABSTRACT

A simple, sensitive, rapid and accurate colorimetric method has been developed for the estimation of edaravone in bulk and pharmaceutical dosage forms. The method is based on the reaction of edaravone with 2, 3-dichloro-5, 6-dicyano-1, 4-benzquinone (DDQ) to form an orange red coloured charge–transfer complex. The orange red colour solution is used to determine the edaravone spectrophotometrically. Results obtained are statistically validated and found to be reproducible.

Keywords: Spectrophotometry, 2, 3-dichloro-5, 6-dicyano-1, 4-benzquinone, edaravone, Pharmaceutical and Formulation.