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ONE-POT SOLVENT-FREE SYNTHESIS, CYTOTOXICITY AND IN VITRO UREASE INHIBITORY ACTIVITY OF ZINC (II)-PIROXICAM COMPLEXMuhammad Amin*
ABSTRACT The solvent-free preparation and characterization of zinc(II)-piroxicam complex, Zn-pir, is described. After comparison of the data of solventfree, one-drop-solvent and solution products it was found that the complex is of ML2 type. Zn-pir was found less toxic than parent drug as evaluated by LD50 values. In Helicobacter pylori urease inhibitory activity, Zn-pir showed significant inhibition. The results of this investigation suggest that Zn-pir can be developed as a safer antiulcer and anti-inflammatory agent. Keywords: Piroxicam, Zinc complexes, NSAIDs, mechanochamical synthesis, urease inhibitory activity. [Download Article] [Download Certifiate] |