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ROLE OF METFORMIN AND L-ARGININE COMBINATION IN SICKLE CELL DISEASE PAINS: A PILOT LABORATORY AND CLINICAL STUDY, AND MINI-REVIEW
Dr. S. E. Oriaifo*, Dr. D. O. Oriaifo and Dr. R. A. Oriaifo
ABSTRACT
Sickle cell disease (SCD) is an inherited disorder of haemoglobin which is frequent in areas of high malaria transmission. Deoxygenation-induced hemoglobin polymerization in SCD is the stimulus for the excessive inflammatory-oxidative cascade-induced pathobiology, where hemolysis and vaso-occlusive episodes with ischaemia-reperfusion are the drivers. SCD is termed a natural model of acute and chronic pain, maintained by peripheral and central sensitization. Metformin and l-arginine through epigenetic mechanisms are disease-modifying agents in SCD. Via the synergistic induction of HbF, they may have additive role in attenuating polymerization and hemolysis, the root causes of SCD pathobiology. The neutrophil, Keywords: Metformin, L-arginine, Nitric Oxide, Sickle Cell Disease, Neutrophil Activation, Acute Pains, Chronic Pains, Glycemic variability. [Download Article] [Download Certifiate] |