Abstract

A REVIEW ON MICRONEEDLES: AN APPROACH IN TRANSDERMAL DRUG DELIVERY

*Jyoti A. Hinge, Vinod M. Thakare and Ujwala N. Mahajan

ABSTRACT

The number of medications and the ways in which they can be administered have expanded dramatically over the years. One such advance has been the development of transdermal delivery systems. Transdermal drug delivery is a validated technology contributing significantly to global pharmaceutical care. Since 1980, impressive growth in this field has been observed with many commercial successes; importantly, a new chemical entity was recently developed and approved for transdermal administration without having first been given as an injectable or oral dosage form Microneedles deliver the drug into the epidermis without disruption of nerve endings. Micro - scale have led to the development and introduction of devices that employ very small needles. Various types of transdermal approaches used to incorporate the active ingredients include use of prodrugs/lipophilic analogs, permeation enhancers, sub saturated systems and entrapment into vesicular systems. Innovations in technologies continue to occur at a positive rate, making the technology a fertile and vibrant. This article deals with the innovations in the field of TDDS to improve the release rate and other parameters and most suitable to the patient. The number of medications and the ways in which they can be administered have expanded dramatically over the years. That has significant potential in devices for diagnostics, healthcare monitoring and drug delivery by mechanically perforating the outer skin layer and allowing for transdermal drug absorption or fluid sampling To make biodegradable polymer microneedles with sharp tips, we adapted micro-electromechanical masking and etching to produce beveled-tip and chisel tip microneedles and developed a new fabrication method to produce tapered-cone microneedles using an in-situ lens-based lithographic approach The concept of drug delivery integrates the dosage form of drug and route of administration. Route administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body.

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