Abstract

FORMULATION AND EVALUATION OF DORZOLAMIDE-LOADED CUBOSOME FOR OCULAR DRUG DELIVERY

Sumithra Devi*, Abilash R., and MD. Shadab pasha

ABSTRACT

The present investigation was aimed to develop and formulate to achieve ocular sustained drug release of Dorzolamide HCl loaded cubosomes. The Dorzolamide loaded cubosomes were prepared using glycerol monooleate and pluronic F127 via top down technique. Finally developed formulation was evaluated for various in-vitro characteristics viz particles size, size distribution, shape and morphology, in-vitro release profile, and stability studies. The optimized drug loaded cubosomal formulation showed mean particle size, polydispersity index, and entrapment 156.90-210.5 nm. 0.139 to 0.223 and 76.65%-92.08%.respectively indicating a relatively narrow size distribution of particles. The zeta potential value was found in the range of -19.8 to -25.6 mV. Results of FT-IR study showed no interaction between drugs and other excipients. The result of stability studies showed that there was no significant change in drug content. The formulation batch C7 containing surfactant: lipid 1:4 ratio of sustained the drug release was found to be (8 hours). The developed sustained ocular drug delivery system (cubosomes) might be a promising system for effective ocular drug delivery.

Keywords: Cubosome, Dorzolamide HCl, Ocular drug delivery, stability studies.