Abstract

EVALUATION OF CARDIOPROTECTIVE ACTIVITY OF POLYALTHIA LONGIFOLIA AGAINST DOXORUBICIN INDUCED SUB ACUTE CARDIOTOXICITY IN RATS

Rajashekar Perusomula* and Ramesh Alluri

ABSTRACT

The cardio toxicity of doxorubicin (DOX) has limited its use as an anticancer drug. The Objective of present study was to investigate the cardio protective effect of Polyalthia longifolia var (Annonaceae) (PL) against the cardio toxicity of Doxorubicin (DOX) in rats. Materials and Methods: Male Wistar rats (200-250 g) were randomly divided into four groups. Group I was vehicle control. Group II animals received Doxorubicin 4 mg/kg i.p. on days 7, 14, 21 and 28. Group III and IV animals were treated with methanol extract of Polyalthia longifolia (PL) (300 and 600 mg/kg, respectively) for 30 days. Doxorubicin was administered on days 7, 14, 21 and 28. After anesthetizing the animals on the 30th day Electrocardiogram (ECG), was recorded and blood was investigated for Creatine Kinase-MB is enzyme (CK-MB), Lactate Dehydrogenase (LDH) and Aspartate Aminotransferase (AST) while determination of Superoxide Dismutase (SOD), Reduced Glutathione (GSH), Lipid Peroxidation (LPO). At the end of the study, the histology of heart was carried out. Results: Group 3 and 4 of animals showed decreased QT and ST interval (p

Keywords: Antioxidant, electrocardiogram, histopathology, cardiotoxicity, tissue parameters.