Abstract

A KINETIC AND MECHANISTIC APPROACH FOR CO(III) CATALYZED OXIDATION OF AMOXICILLIN BY COPPER (III) PERIODATE COMPLEX IN ALKALINE MEDIUM

Yuv Raj Sahu, Parashuram Mishra, Shivamurti A. Chimatadar and Sharanappa T. Nandibewoor*

ABSTRACT

The kinetics and mechanism of Co(III) catalyzed oxidation of Amoxicillin by diperiodatocuprate (DPC(III)) in aqueous alkaline medium is studied spectrophotometrically at 298 K and ionic strength of 0.10 mol dm-3. The reaction between DPC and Amoxicillin in alkaline medium exhibits (AMOX:DPC)1:2 stoichiometry. The reaction products were identified by spot test, FT-IR, LC-MS and GC-MS spectral studies. The reaction is of pseudo -first order with respect to DPC and fractional order with respect to amoxicillin. Addition of both alkali and Co (III) enhances the rate and periodate possesses retarding effect on rate. Monoperiodatocuprate MPC(III) is found to be the main active species in alkaline medium in the form of [Cu(H2IO6)(H2O)2]. Activation parameters are computed. The plausible mechanism consistent with experimental results has been proposed and discussed in detail.

Keywords: Kinetics; Mechanism; Oxidation; Amoxicillin, Diperiodatocuprate (III).