Abstract

A CLINICAL STUDY ON EFFECT OF CASSIA TORA LINN. AND OCIMUM SANCTUM LINN. IN DRUG RESISTANCE CASE OF TINEA CORPORIS

Dr. Abhijeet Pachpor*, Dr. D. V. Kulkarni, Dr. Parshuram Dongre, Dr. Najneen Bhaldar, Dr. Surekha Khandekar and Dr. Sharadkumar Maurya

ABSTRACT

Tinea corporis is a superficial dermatophyte infection characterized by either inflammatory or non-inflammatory lesions on the glabrous skin (i.e. skin regions other than the scalp, groin, palm and soles).[1] Dermatophytosis or ringworm is a clinical condition caused by fungal infection of the skin in humans, popularly called as tinea or ringworm.[2] Tinea corporis shows clinical manifestations like erythematous legends with scaly plaque that may rapidly version large into erythematous, scaly plaque. Interior topical therapy is recommended for a localised infection because dermatophytes rarely invaded living tissues. Topical azoles and Alia mines show high rates of clinical efficacy; these agents inhibit the synthesis of ergosterol a major fungal cell membrane sterol. The topical azoles inhibit the enzyme lanosterol that converts lanosterol to ergosterol. Inhibition of this enzyme results in unstable fungal cell membranes and causes membrane leakage as a result fungus cell gets destroyed. Also the azoles are cytotoxic if taken orally for long duration. Decide this recurrence and resistance to these drugs is very common and the conditions version when this azoles and earlier mines are combined with steroids. Acharya Bhavprakasha has mentioned two commonly available herbs viz. Cassia tora as Dadrughna (चक्रं दद्रुरोगं मददयति इति।) and Ocimum sanctum Linn. as Kushthaghna (ददपनी कुष्ठकृच्छ्रास्त्र...।) respectively. The present work has been undertaken to study efficacy of Patra swaras, Beeja choorna of Cassia tora Linn. and Ocimum sanctum Linn. in management of tinea corporis. A case report of 28 year old male presented with erythematous and scaly lesions of tinea corporis with pruritus, which remained recurrent and resistant to azole and allylamines drugs will be presented in the paper.

Keywords: Tinea corporis, Cassia tora Linn. Ocimum sanctum Linn. Dadruroga.