Abstract

DIRECT COMPRESSION METHOD

Ajesh Chauhan, Dr. Seema Rohilla* and Dr. Saroj Jain

ABSTRACT

From decades pharmaceutical dosage forms have been used for the treatment of different diseases. Solid oral dosage forms are used mainly because of ease of administration and they are suitable for delivery of drugs for systemic effects. In present days pellets, capsules, granules and tablets are most commonly used pharmaceutical solid dosage forms for oral use. Tablets and capsules can be made from powders, granules or from pellets granules. Capsules are also made from semisolid ingredients. Out of these dosage forms tablets are most popular. Tablets are produces as about 70% of all ethical pharmaceutical dosage form. Tablets are defined as the pharmaceutical dosage forms which contain one or more than one active pharmaceutical ingredients with or without suitable ingredients. Tablets are made by either by compression or moulding methods. On the basis of process of manufacturing tablets are broadly classified as compressed tablets and moulded tablets. Further classification of compressed tablets is as directly compressed tablets, chewable tablets, tablet triturates. Direct compression is one of the preferred method of the tablets preparation. In direct compression method blends of active pharmaceutical ingredients (API) with suitable ingredients are prepared. These blends are compressed directly by using tablet press to form a suitable tablet. The present review outlines the importance of the directly compression method of tablet manufacturing with its advantage and disadvantages, excipients used in process and various challenges in process.

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