Abstract

PRECLINICAL SCREENING OF RAPHANUS SATIVUS VAR. LONGINNATUS LEAVES EXTRACTS FOR ANTI-DIABETIC ACTIVITY

Kumari Sachin*, Farheen Shareef and Saurabh Sharma

ABSTRACT

Diabetes is a disease that occurs when your blood glucose, also called blood sugar, is too high. Blood glucose is your main source of energy and comes from the food you eat. Insulin, a hormone made by the pancreas, helps glucose from food get into your cells to be used for energy. Sometimes your body doesn’t make enough—or any—insulin or doesn’t use insulin well. Glucose then stays in your blood and doesn’t reach your cells. Raphanus sativus is a traditional plant who is used to lower plasma lipid. The aim of this study was to evaluate the effect of hydroalcoholic extract of Raphanus Sativus on plasma glucose, triglyceride, and cholesterol in diabetic rats. For this purpose, 6 male rats were selected, maintained in standard conditions and divided randomly into 6 groups. Streptozotocin (45 mg/kg) was given IP to induce diabetes in 1 week. The hydroalcoholic extract of Raphanus sativus was given orally to the experimental groups at doses of 100,200 and 400 mg/kg once daily for 21 days by a feeding needle. At days 0, 10, and 21, blood samples were taken from the tail vein of all the groups.

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