Abstract

SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL SCREENING OF NOVEL QUINOXALINE DERIVATIVES FOR ANTI-INFLAMMATORY ACTIVITY

Anamika Tom*, Mathew George and Lincy Joseph

ABSTRACT

Quinoxaline is a fused six-membered ring with two nitrogen atoms as heteroatoms. Inorganic chemistry, it is an aromatic heterocyclic compound containing a ring complex made up of a benzene and pyrazine ring. Quinoxaline derivatives are well known in the pharmaceutical industry and have been shown to possess a broad spectrum of biological activities. Novel quinoxaline derivatives synthesized by refluxing phenylenediamine with various monosaccharides. The structure of all these title compounds was confirmed by their IR, NMR, and elemental analysis. All the newly synthesized heterocycles have been screened for their in vitro and in vivo anti-inflammatory activities by Protein denaturation and Carrageenan-induced paw edema in rats respectively. Results showed that all of them exhibited promising anti-inflammatory activity.

Keywords: Quinoxaline, inflammation, Anti-inflammatory activity.