Abstract

EVALUATION OF ANTI ULCER ACTIVITY OF PITHECELLOBIUM DULCE (SEEDS) IN RATS USING PYLORUS LIGATION

Palanivel*, Sorabh Kumar Agrawal Manjulvani, Senthil Kumar K ,Venkatachalam Karthikeyan, Parthiban Periyasamy and Sivakumar GM

ABSTRACT

The present investigation was designed to evaluate a novel gastro protective drug from indigenous plant Pithecellobium dulce which may be potent and nontoxic or minimal toxic. The anti ulcer effect was investigated in the seeds of Pithecellobium dulce. The powder of Pithecellobium dulce seeds was successively extracted with Petroleum ether, Ethyl alcohol and water. The preliminary phytochemical tests were done and the LD50 value for both alcohol and aqueous extract was determined. The anti ulcer activity of the alcoholic (100 mg / kg. p.o.) and aqueous extract (100 mg / kg. p.o.) were assessed in pyloric ligation induced gastric ulcer. The results indicate that alcoholic and aqueous extract of Pithecellobium dulce (100mg/kg) seeds was effective in protecting ulcers in pyloric ligated rats and significantly decreased the gastric volume, total acidity, free acidity and ulcer index when compared with the standard group. The experimental investigation on Pithecellobium dulce seeds extract revealed that it possesses remarkable anti ulcer effect and it may be used for the effective treatment of peptic ulcer disease.

Keywords: Pithecellobium dulce, Pyloric ligation, Gastric Volume, Peptic ulcer, Ranitidine.