Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE RIVAROXABAN TABLETS

Bidkar S.J., Sadakal S.U.*, Dr. Dama G.Y., Bidkar J.S, Dr. Umalkar D.G

ABSTRACT

The present work is to formulate and evaluate immediate release tablets of Rivaroxaban tablets. Rivaroxaban is an anticoagulant medication (blood thinner), which is taken by orally. Tablets were prepared by direct compression method. Eight different formulations were made (F1-F8) using different super disintegrating agents. Using different Superdisintegrant and different concentrations of excipients. Concentration of SLS and PVPK-30 concentration were varied for all batches. Dissolution of rivaroxaban IR tablet was carried out in 900ml buffer at 75rpm by taking the concentrations of PVPK-30 and SLS. Dissolution of IR tablet of rivaroxaban containing different concentration of PVP K-30 changes the dissolution profile. When 5% and 8% PVP K-30 is used in the formulation the release of drug from IR tablet of rivaroxaban is decreased as compared to 2.5%. While using 6% and 8% of SLS in the formulation, it showed maximum release of drug from tablet as compared to 4% of SLS. From all the batches f7 batch shows best results as compare to other formulations.

Keywords: Immediate release, super disintegrating agents, Dissolution, Direct Compression.