Abstract

PREPARATION AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM OF METOPROLOL SUCCINATE MICROBALLOONS

Khandagale K. S.*, Tarkase K. N. and Tarkase M. K.

ABSTRACT

Oral administration for Systemic circulation is the most convenient and preferred in Gastroretentive drug delivery system (GDDS). Low cost, ease of the administration and manufacturing process as well as flexibility in the formulation and higher level of patient compliance, make the oral route the most preferred and promising route of administration of therapeutic agent.Floating drug delivery systems (FDDS) have a lower bulk density than gastric fluids (˃1g/cm2) and thus remain buoyant in stomach for a prolonged period of time, without affecting the gastric emptying rate. The current study was to preparation and evaluate Microballons for metoprolol succinate. The Microballoons of metoprolol succinate was prepared by solvent evaporation technique by using different polymer ratio. The polymers were PEG and EC at different ratio. The effect of various formulation and process variables on the internal and external particle morphology, micromeritic properties, in vitro floating behaviour, physical state of the incorporated drug, drug loading and in vitro drug release was studied. The release rate was determined in simulated gastro-intestinal fluids at 37oc. The designed system, combining excellent buoyant ability and suitable drug release pattern, could possibly be advantageous in terms of bioavailability of

Keywords: Metoprolol Succinate, Gastroretentive Drug Delivery Systems, Polyethylene Glycol (PEG), Ethyl Cellulose (EC).