Abstract

FORMULATION AND EVALUATION OF ACECLOFENAC MICROEMULSION GEL

Mamatha G. T.*, Swathi K. C., Rani Abraham, Vidyashree and Sharon P.

ABSTRACT

The objective of the present study was to incorporate poorly soluble Aceclofenac (ACF) into microemulsion based formulation. In present study microemulsion was prepared with 6% w/w Isopropyl Myristate (IPM), 27%w/w Tween 80 & 18%w/w PEG-400 as oil, surfactant & Cosurfactant qrespectively. The ratio of surfactant: cosurfactant was fixed at 4:1 on the basis of Ternary phase diagram. Microemulsion gel was prepared using 1% Carbopol 934 as a gelling agent. Optimized formulation was evaluated for drug content, zeta potential, droplet size, drug assay, pH, viscosity, In-Vitro drug release profile. Globule size of optimize batch ACF 5 was found to be 11.50 ± 0.5 nm. In-Vitro release study had shown 21.72 ± 1.50 % drug release from microemulsion gel.

Keywords: Aceclofenac; Tween 80; PEG 400; Carbopol 934.