Abstract

SYNTHESIS OF 4-(BIPHENYL-4-YL)-2-(SUBSTITUTED PHENYL)-1H- IMIDAZOLE DERIVATIVES AS EFFECTIVE ANTIMICROBIAL AGENTS

Bipin Kumar Vermaa* and Girendra Gautam

ABSTRACT

In the present work, some new imidazole derivatives (3i-xii) were synthesized as per design synthetic protocol scheme. The structures of newly prepared compounds were confirmed by modern analytical technique (IR, 1H-NMR, Mass spectral data) and elemental analysis, results found in full agreement with their assigned structures. All the synthetic compounds were screened for their antimicrobial activity against bacterial strains and fungal strains; results showed good to remarkable activity. The MIC (minimum inhibitory concentration) values were determined by comparison to ciprofloxacin (anti-bacterial) and fluconazole (anti-fungal) as standard drug. Among them, compound 3iv and 3x exhibited notable antimicrobial activity. These compounds may be used as new template for the searching of potential antimicrobial agents.

Keywords: Imidazole, Biphenyl ethanone, Antibacterial activity and Antifungal activity.