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FORMULATION AND EVALUATION OF METFORMIN MUCOADHESIVE BUCCAL PATCHES
Ganesh N. Patil*, Vaibhav K. Patil, Sandip A. Tadvi, Sulbha G. Patil, Dr. Sunil P. Pawar
ABSTRACT The buccal region of the oral cavity is an attractive target for administration of the drug of choice. To increse bioavailability and prevent first pass metabolism of drug. The aim of present research work was to design and evaluate mucoadhesive buccal patch of Metformin as BCS class II drug to provide controlled predetermined manner drug delivery to the oral mucosa. The patches were prepared using hydroxy propyl methyl cellulose (HPMC K4M & K15) as a mucoadhesive polymers and polyethylene glycol 4000 was used as a plasticizer, the buccal patches are prepared by the solvent casting method. The patches were evaluated for different physical parameters. The prepared patches shows smooth in appearance, uniform thickness, and required surface pH, moisture content, Drug content showed no visible cracks, and show good folding endurance. Results are observe satisfactory. It is also observe that the amount of polymer significantly influenced characteristics like swelling index, mucoadhesive strength and In vitro drug release studies were conducted for Metformin buccal patches in phosphate buffer (pH6.8) patches exhibited drug release in the range of more than 101.68% and stability study. Keywords: Mucoadhesive Buccal patches, Metformin, HPMC K 4M, HPMC K 15. [Download Article] [Download Certifiate] |