Abstract

FORMULATION AND EVALUATION OF HERBAL GEL CONTAINING EXTRACT OF CYNODON DACTYLON Linn

Dr. Belvotagi V. Adavirao, Akash A. Patil*, Naushad N. Mirza, Manmant B. Rumane, Aniket S. Katte and Nagesh S. Kote

ABSTRACT

Cynodon dactylon linn. Is a medicinal plant and has high wound healing activity, antioxidant activity, Antidiabetic activity, Antidiarrheal, Immunomodulator, Antiulcer and cardio protective. There are many reports revealing pharmacological potential of Cynodon dactylon Linn. extracts however, only few literature reports highlight the conversion of these extract in to suitable dosage. The objective of the present research work is to formulate and evaluate Herbal Gel for Wound healing Activity. This formulation is made for better patient compliance and to reduce the dose of the drug. The gel was formulated by changing the polymer ratio. Various formulation (F1, F2, F3, F4) were developed by using a suitable polymer (Carbopol 971p and NoveonAA1). The formulation was evaluated for spreadability, extrudability and viscosity in vitro drug release study. Viscosity studies of various formulations revealed that formulation F4 was better to compare to others. From among all the developed formulation, F4 shows better drug diffusion, did good Rheological properties. pH of the F4 formulation is sufficient enough to treat the skin infections. Results indicated that the concentration of Carbopol 971p and Noveon AA1 significantly affects drug release and rheological properties of the gel. It was concluded that formulation F4 was the best formulation among this formulation. Hence formulation F4 has shown the better results compared to other batches.

Keywords: Carbopol 971 p, Cynodon dactylon linn, Herbal Gel, Noveon AA1,