Abstract

TASTE MASKING: IMPLEMENTED TECHNIQUES WITH PATENTS

Vani Madaan*, Ajay Bilandi and Mahesh Kumar Kataria

ABSTRACT

Taste is a critical factor in development of an acceptable oral dosage form. Taste masking is an important factor for bitter drugs to improve the patient compliance especially in the pediatric and geriatric populations. Two approaches commonly used to overcome the bitter taste of drug are reduction of drug solubility in the saliva and alteration of the ability of the drug to interact with taste receptors. These techniques not only mask the taste of drug, but also may enhance the bioavailability of dosage form. The recent techniques of taste masking are inclusion complexation, use of ion exchange resin, mass extrusion, and solid dispersions, coating granulation, spray drying, microencapsulation, liposomes, emulsions and gel formation effervescence. This review emphasizes on the basics of taste, different techniques and patents related to taste masking of drug.

Keywords: Taste Masking Techniques, Physiology of tongue, Taste buds, Ion exchange resins, Prodrug design.