Abstract

COMPARATIVE STUDY FOR PERCENTAGE PURITY DETERMINATION OF DIFFERENT BRANDS OF PARACETAMOL TABLETS AVAILABLE IN THE LOCAL MARKET BY UVSPECTROSCOPY AND TITRATION METHODS

Khoo Jing Han, Nabila Perveen and Naeem Hasan Khan*

ABSTRACT

Paracetamol is also known as acetaminophen. Its systematic (IUPAC) name is N-(4-hydroxyphenyl) ethanamide or N-(4-hydroxyphenyl) acetamide. In some contexts, it is simply abbreviated as APAP. In 1893, it was firstly introduced into medicine by Von Mering. It is a popular over-the-counter drug.[1-4] The structure of paracetamol is shown in Figure 1. It consists of a benzene ring core, substituted by one hydroxyl group and the nitrogen atom of an amide group in the para (1,4) pattern. The amide group is acetamide (ethanamide). The chemical formula of paracetamol is C8H9NO2.

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