Abstract

DEVELOPMENT AND EVALUATION OF FLOATING SUSTAINED RELEASE BILAYER TABLETS CONTAINING IRBESARTAN

Rajesh J. S., Manjunath K.* and Suresh V. Kulkarni

ABSTRACT

Bilayer floating tablets of Irbesartan were developed by direct compression method. Immediate release layer contains 30 mg of drug and super disintegrant sodium starch glycolate, serves the purpose of loading dose. Sustained release layer contained HPMC K4M, natural polymers like xanthan gum, guar gum, locust bean gum, karaya gum release the drug for 12 hrs time. Sodium bicarbonate and citric acid are used to produce effervescence. Floating lag time of optimised tablet is 92 sec, whereas floating duration is more than 12 hrs. FTIR results revealed that there was no interaction between drug and HPMC K4M / xanthan gum. The post compression parameters of developed tablets are satisfactory. In this study, it was confirmed that the formulations containing HPMC K4M, have shown better floating properties and finally the formulation containing a combination of HPMC K4M and xanthan gum in 3:1 ratio, has shown sustain in vitro drug release properties. The release kinetics of optimized formulation prepared with the combination of HPMC K4M and xanthan gum followed zero order kinetics.

Keywords: Floating Bilayer Tablet, Irbesartan, HPMC K4M, Xanthan Gum, FTIR.