Abstract

FORMULATION AND EVALUATION OF PANTOPRAZOLE SODIUM MICROSPHERES BY USING IONOTROPIC GELATION TECHNIQUE

Dipak A. Patil*, Nilesh P. Salunke, Sandip A. Tadavi and Sunil P. Pawar

ABSTRACT

Microspheres are typically free flow powders consisting of proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 μm. microsphere after ball bearing effects because of their spherical shape. The therapeutic efficacy of microspheres contain drug depends upon their characteristics that can be altered in required terms by altering materials, methods, polymers or techniques used. The Microspheres were prepared by Ionotropic gelation method dispersing Pantoprazole sodium separately into mixture of ionic sodium alginate. As primary polymer with oppositely charged ion polymer, namely HPMC and SCMC of both polymer, in to a solution of calcium chloride solution. Microspheres constitute an important part of novel drug delivery system by virture of their small size and efficient carrying capacity. The Micro carrier were evaluate for micrometric properties, production yield, drug loading, and in vitro drug release studies. The size of prepared microspheres were in the range of 447.1 to 650.2 μm. The result of this study indicate that HPMC K15M gives fast released pattern of the drug as compare to SCMC.

Keywords: Microspheres, Controlled released, Novel drug delivery, Target site, Sodium alginate, Pantoprazole Sodium.