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FORMULATION DEVELOPMENT AND EVALUATION OF ZOLMITRIPTAN HYDROCHLORIDE ORAL JELLY COMPARATIVE WITH MARKETED PRODUCT
V. R. Malviya* and S. D. Pande
ABSTRACT The present study aimed to develop an immediate release of zolmitriptan hydrochloride oral jellies for the treatment of severe migraine. The jellies were prepared by using chitosan hydrochloride with different concentration as a polymer and propylene glycol as a co-polymer. The prepared jellies were evaluated for its various physio-chemical parameters such as pH, appearance, viscosity, in vitro drug release and drug content. The pH of the prepared formulations was found to be in the range of 7.5-8.1. The appearance of the prepared formulations was transparent to opaque. The viscosity of the prepared jellies was found to be in the range of 273600 - 542335 CPS. The drug content of the prepared jellies was found to be more than 97%. The in vitro drug release immediate release with increased concentration of Chitosan Hydrochloride, and the drug release was found to be more than 60% in 15 minutes. This present studies concluded that zolmitriptan hydrochloride oral jellies can be a better alternative for oral dispersible tablets and it could produce improved bioavailability as compared to other fast releasing dosage form. From the above studies of various parameter, it was concluded that the FJ5 formulation was found to be optimized formulation. Keywords: Oral Jelly, Migraine, Zolmitriptan Hydrochloride, Chitosan Hydrochloride. [Download Article] [Download Certifiate] |