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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

DEVELOPMENT AND VALIDATION OF SPECTROSCOPIC ESTIMATION BY AREA UNDER CURVE METHOD OF EPERISONE HYDROCHLORIDE WITH ACECLOFENAC

Suchita Khot*, Dr. Amol Kulkarni, Dr. Vrushali Kashikar, Manisha Khaire and Sujit Patil

ABSTRACT

A simple, sensitive, rapid and reproducible UV method has been developed and validated for simultaneous determination of Eperisone Hydrochloride (EPE) and Aceclofenac Sodium (ACE) in bulk and in Laboratory mixture. RP - HPLC methods has been developed and validated for simultaneous determination of Eperisone Hydrochloride (EPE) and Ibuprofen (IBU) in bulk and in Laboratory mixture. For development of UV method for EPE and ACE methanol was used as a solvent and detection wavelengths were found to be at 255 nm and 277 nm respectively. The method was found to be linear in concentration range 2-10 μg/mL for both drugs. The method was validated as per ICH guidelines. The Recovery study, precision and repeatability results showed % RSD less than 2%. The method is found to be robust & rugged.

Keywords: Eperisone hydrochloride, Aceclofenac, Simultaneous equation method, Q – ration analysis, Area under curve method, UV.

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