Abstract

FORMULATION AND IN-VITRO EVALUATIONS OF VENLAFAXINE SUSTAINED RELEASE MATRIX TABLET

Kailas N. Tarkase and Sandesh Bole*

ABSTRACT

This study examines the sustained release behaviour of the Venlafaxine from Carbopol 934 & Xanthan Gum. Venlafaxine is an antidepressant drug which used to reduce the depression with an aim of improving patient compliance, better therapeutic efficacy, less side effects and reduced dosage regimen with less toxicity for treatment for many acute and chronic diseases. In present research attempt was made to develop the sustained release dosage form of Venlafaxine in form of matrix tablets to be taken only once a day. All formulations were prepared by the direct compression technique. All compressed tablets were evaluated for thickness, hardness, friability, uniformity of weight, content of active ingredients and In-vitro dissolution studies. Drug dissolution studies were carried out by using the USP type II (paddle) apparatus in 900 ml of 6.8 phosphate buffer solution as dissolution media for drug release profile. Drug release kinetics was analyzed by Zero-order, First-order, Higuchi and Korsmeyer-Peppas exponential equations. All of these formulations were found to comply with the pharmacopeial standards. Among all the formulations (F1-F9) F8 containing (Carbopol 934 containing 20% and Xanthan Gum containing 30%) was the optimized formulation with the sustained release drug for up to 12 hours and 96.2% of drug release predominantly. Thus the matrix system of Carbopol 934 and Xanthan Gum was found to be effective in regarding sustained release of Venlafaxine matrix tablet.

Keywords: Venlafaxine, Matrix tablet, Drug delivery system, In-vitro drug release etc.